Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation

Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation

A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus PIII/PV redox catalysis is reported. The method employs a phosphetane catalyst together with a mild bromenium oxidant and terminal hydrosilane reductant to drive successi...

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Bibliographic Details
Main Authors: Lecomte, Morgan, Lipshultz, Jeffrey M., Kim-Lee, Shin-Ho, Li, Gen, Radosevich, Alexander T.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: American Chemical Society (ACS) 2020
Subjects:
Colloid and Surface Chemistry
Biochemistry
General Chemistry
Catalysis
Online Access:https://hdl.handle.net/1721.1/124882

Internet

https://hdl.handle.net/1721.1/124882

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