Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/1721.1/124926 |