Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

Huntington’s disease (HD) is a chronic neurodegenerative disorder characterized by a late clinical onset despite ubiquitous expression of the mutant Huntingtin gene (HTT) from birth. Transcriptional dysregulation is a pivotal feature of HD. Yet, the genes that are altered in the prodromal period and...

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Bibliographic Details
Main Authors: Yildirim, Ferah, Ng, Christopher, Kappes, Vincent, Ehrenberger, Tobias, Rigby, Siobhan K., Stivanello, Victoria, Gipson, Theresa A., Soltis, Anthony R., Vanhoutte, Peter, Caboche, Jocelyne, Housman, David E., Fraenkel, Ernest
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/124935

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https://hdl.handle.net/1721.1/124935

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