Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice

Chimeric antigen receptor (CAR) T cell therapy has been successful in clinical trials against hematological cancers, but has experienced challenges in the treatment of solid tumors. One of the main difficulties lies in a paucity of tumor-specific targets that can serve as CAR recognition domains. We...

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Bibliographic Details
Main Authors: Xie, Yushu Joy, Dougan, Michael, Jailkhani, Noor, Ingram, Jessica, Fang, Tao, Kummer, Laura, Momin, Noor, Pishesha, Novalia, Rickelt, Steffen, Hynes, Richard O., Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/124961

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https://hdl.handle.net/1721.1/124961

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