Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multiple malignancies, but the stromal composition of breast cancer m...

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書目詳細資料
Main Authors: Chen, Ivy Xiaoyu, Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle W., Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert S, Jain, Rakesh K.
其他作者: Massachusetts Institute of Technology. Department of Chemical Engineering
格式: Article
語言:English
出版: National Academy of Sciences 2020
在線閱讀:https://hdl.handle.net/1721.1/125038