Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multiple malignancies, but the stromal composition of breast cancer m...

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Bibliographic Details
Main Authors: Chen, Ivy Xiaoyu, Chauhan, Vikash P., Posada, Jessica, Ng, Mei R., Wu, Michelle W., Adstamongkonkul, Pichet, Huang, Peigen, Lindeman, Neal, Langer, Robert S, Jain, Rakesh K.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/125038

Internet

https://hdl.handle.net/1721.1/125038

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