Induction and transcriptional regulation of the co-inhibitory gene module in T cells
The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory receptors on CD4+ T cells promotes autoimmunity, whereas sustained overexpression on CD8+ T cells promotes T cell dysfu...
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| Format: | Article |
| Language: | English |
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Springer Nature
2020
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| Online Access: | https://hdl.handle.net/1721.1/125051 |