The damaging effect of passenger mutations on cancer progression

The damaging effect of passenger mutations on cancer progression

Genomic instability and high mutation rates cause cancer to acquire numerous mutations and chromosomal alterations during its somatic evolution; most are termed passengers because they do not confer cancer phenotypes. Evolutionary simulations and cancer genomic studies suggest that mildly deleteriou...

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Bibliographic Details
Main Authors: McFarland, Christopher D., Yaglom, Julia A., Wojtkowiak, Jonathan W., Scott, Jacob G., Morse, David L., Sherman, Michael Y., Mirny, Leonard A
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: American Association for Cancer Research (AACR) 2020
Online Access:https://hdl.handle.net/1721.1/125061

Internet

https://hdl.handle.net/1721.1/125061

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