Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in oleic acid (OA, 18:1), digly...

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Main Authors: Fanning, Saranna, Haque, Aftabul, Imberdis, Thibaut, Baru, Valeriya, Barrasa, M. Inmaculada, Nuber, Silke, Termine, Daniel, Ramalingam, Nagendran, Ho, Gary P.H., Noble, Tallie, Sandoe, Jackson, Lou, Yali, Landgraf, Dirk, Freyzon, Yelena, Newby, Gregory, Soldner, Frank, Terry-Kantor, Elizabeth, Kim, Tae-Eun, Hofbauer, Harald F., Becuwe, Michel, Jaenisch, Rudolf, Pincus, David, Clish, Clary B., Walther, Tobias C., Farese, Robert V., Srinivasan, Supriya, Welte, Michael A., Kohlwein, Sepp D., Dettmer, Ulf, Lindquist, Susan, Selkoe, Dennis
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125128

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https://hdl.handle.net/1721.1/125128

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