Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology

Uveal melanoma (UM) is the most common primary intraocular cancer and has a high incidence of metastasis, which lacks any effective treatment. Here, we present zebrafish models of UM, which are driven by melanocyte-specific expression of activating GNAQ or GNA11 alleles, GNAQ/11 Q209L , the predomin...

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Bibliographic Details
Main Authors: Perez, Dahlia E., Henle, Andrea M., Amsterdam, Adam, Hagen, Hannah R., Lees, Jacqueline A.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/125206

Internet

https://hdl.handle.net/1721.1/125206

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