Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology
Uveal melanoma (UM) is the most common primary intraocular cancer and has a high incidence of metastasis, which lacks any effective treatment. Here, we present zebrafish models of UM, which are driven by melanocyte-specific expression of activating GNAQ or GNA11 alleles, GNAQ/11 Q209L , the predomin...
Main Authors: | Perez, Dahlia E., Henle, Andrea M., Amsterdam, Adam, Hagen, Hannah R., Lees, Jacqueline A. |
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Other Authors: | Koch Institute for Integrative Cancer Research at MIT |
Format: | Article |
Language: | English |
Published: |
Wiley
2020
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Online Access: | https://hdl.handle.net/1721.1/125206 |
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