Quantification of somatic mutation flow across individual cell division events by lineage sequencing
Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide methods have a limited ability to resolve rare som...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory
2020
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| Online Access: | https://hdl.handle.net/1721.1/125233 |