Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture

Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that...

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Bibliographic Details
Main Authors: Knouse, Kristin Ann, Bachofner, Marc, Amon, Angelika B, Lopez-Bernal, Kristina Elizabeth, 1980-
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125270