Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture
Much of our understanding of chromosome segregation is based on cell culture systems. Here, we examine the importance of the tissue environment for chromosome segregation by comparing chromosome segregation fidelity across several primary cell types in native and nonnative contexts. We discover that...
Main Authors: | Knouse, Kristin Ann, Bachofner, Marc, Amon, Angelika B, Lopez-Bernal, Kristina Elizabeth, 1980- |
---|---|
Other Authors: | Koch Institute for Integrative Cancer Research at MIT |
Format: | Article |
Language: | English |
Published: |
Elsevier BV
2020
|
Online Access: | https://hdl.handle.net/1721.1/125270 |
Similar Items
-
Short- and long-term effects of chromosome mis-segregation and aneuploidy
by: Santaguida, Stefano, et al.
Published: (2018) -
The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation
by: Brito, Ilana Lauren, et al.
Published: (2011) -
Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System
by: Richardson, Amelia, et al.
Published: (2018) -
Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions
by: Miller, Matthew P., et al.
Published: (2014) -
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues
by: Wu, Jie, et al.
Published: (2015)