Diversity, classification and evolution of CRISPR-Cas systems

The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex structure, genome locus architecture and mechanisms of adaptation, pre-CRISPR (cr)RNA processing and interference. The CRISPR-Cas systems belong to two classes, with...

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Bibliographic Details
Main Authors: Koonin, Eugene V, Makarova, Kira S, Zhang, Feng
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125357