Diversity and evolution of class 2 CRISPR–Cas systems

Diversity and evolution of class 2 CRISPR–Cas systems

Class 2 CRISPR-Cas systems are characterized by effector modules that consist of a single multidomain protein, such as Cas9 or Cpf1. We designed a computational pipeline for the discovery of novel class 2 variants and used it to identify six new CRISPR-Cas subtypes. The diverse properties of these n...

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Bibliographic Details
Main Authors: Shmakov, Sergey, Smargon, Aaron Andrew, Scott, David (David Arthur), Cox, David D., Pyzocha, Neena, Yan, Winston Xia, Abudayyeh, Omar O., Gootenberg, Jonathan S, Makarova, Kira S., Wolf, Yuri I., Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/125361

Internet

https://hdl.handle.net/1721.1/125361

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