Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

© van de Kooij et al. Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases strongly select for hydrophobi...

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Bibliographic Details
Main Authors: Van de Kooij, Bert, Creixell Morera, Pau, Van Vlimmeren, Anne Elise, Joughin, Brian Alan, Yaffe, Michael B
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2020
Online Access:https://hdl.handle.net/1721.1/125507

Internet

https://hdl.handle.net/1721.1/125507

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