An n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole

An n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole

Aspartic proteases regulate many biological processes and are prominent targets for therapeutic intervention. Structural studies have captured intermediates along the reaction pathway, including the Michaelis complex and tetrahedral intermediate. Using a Ramachandran analysis of these structures, we...

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Bibliografiske detaljer
Main Authors: Windsor, Ian William, Gold, Brian, Raines, Ronald T
Andre forfattere: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Sprog:English
Udgivet: American Chemical Society (ACS) 2020
Online adgang:https://hdl.handle.net/1721.1/125571

Internet

https://hdl.handle.net/1721.1/125571

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