Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing other pathogenic effects. We have analyzed RBCs in hereditary spherocytosis (HS) and hereditary elliptocytosis (HE),...

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Bibliographic Details
Main Authors: Li, He, Lu, Lu, Li, Xuejin, Buffet, Pierre A., Dao, Ming, Karniadakis, George E., Suresh, Subra
Other Authors: Massachusetts Institute of Technology. Department of Materials Science and Engineering
Format: Article
Language:English
Published: National Academy of Sciences (U.S.) 2020
Online Access:https://hdl.handle.net/1721.1/125836