Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

All cells obtain 2′-deoxyribonucleotides for DNA synthesis through the activity of a ribonucleotide reductase (RNR). The class I RNRs found in humans and pathogenic bacteria differ in (i) use of Fe(II), Mn(II), or both for activation of the dinuclear-metallocofactor subunit, β; (ii) reaction of the...

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Bibliographic Details
Main Authors: Blaesi, Elizabeth J., Palowitch, Gavin M., Hu, Kai, Kim, Amelia J., Rose, Hannah R., Alapati, Rahul, Lougee, Marshall G., Kim, Hee Jong, Taguchi, Alexander T, Tan, Kong Ooi, Laremore, Tatiana N., Griffin, Robert Guy, Krebs, Carsten, Matthews, Megan L., Silakov, Alexey, Bollinger, J. Martin, Allen, Benjamin D., Boal, Amie K.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/125856

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https://hdl.handle.net/1721.1/125856

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