Thiazolidin-5-imine Formation as a Catalyst-Free Bioorthogonal Reaction for Protein and Live Cell Labeling

A previously undescribed reaction involving the formation of a thiazolidin-5-imine linkage was developed for bio-conjugation. Being highly specific and operating in aqueous media, this simple condensation reaction is used to chemoselectively label peptides, proteins and living cells under physiologi...

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Bibliographic Details
Main Authors: Bi, Xiaobao, Yin, Juan, Rao, Chang, Balamkundu, Seetharamsing, Zhang, Dingpeng, Dedon, Peter C, Liu, Chuan-Fa
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: American Chemical Society (ACS) 2020
Online Access:https://hdl.handle.net/1721.1/125905