Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-targeting agents (MTAs) are widely used chemotherapy drugs capable of disrupting microtubule-dependent cellular functions, such as division and migration. We show that two clinically approved MTAs, paclitaxel and vinblastine, each suppress stiffness-sensitive migration and polarization c...

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Bibliographic Details
Main Authors: Prahl, Louis S., Bangasser, Patrick F., Stopfer, Lauren Elizabeth, Hemmat, Mahya, White, Forest M., Rosenfeld, Steven S., Odde, David J.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Cell Press 2020
Online Access:https://hdl.handle.net/1721.1/125946