7-step flow synthesis of the HIV integrase inhibitor Dolutegravir

7-step flow synthesis of the HIV integrase inhibitor Dolutegravir

Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir, DTG was produced in 4.5 h in sequential flow...

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Bibliographic Details
Main Authors: Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo-Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/125949

Internet

https://hdl.handle.net/1721.1/125949

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