Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive immunization, but the immunological mechanisms that drive their development are poorly understood. Structural features of bNAbs indicate that they originate from extensive germinal center (GC) selection, which relie...

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Bibliographic Details
Main Authors: Lofano, Giuseppe, Gorman, Matthew J., Yousif, Ashraf S., Yu, Wen-Han, Fox, Julie M., Dugast, Anne-Sophie, Ackerman, Margaret E., Suscovich, Todd J., Weiner, Joshua, Barouch, Dan, Streeck, Hendrik, Little, Susan, Smith, Davey, Richman, Douglas, Lauffenburger, Douglas A, Walker, Bruce, Diamond, Michael S., Alter, Galit
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2020
Online Access:https://hdl.handle.net/1721.1/125968

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