Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profile during the course of cell culture processes accurately....

詳細記述

書誌詳細
主要な著者: Sumit, Madhuresh, Dolatshahi, Sepideh, Chu, An-Hsiang Adam, Cote, Kaffa, Scarcelli, John J., Marshall, Jeffrey K., Cornell, Richard J., Weiss, Ron, Lauffenburger, Douglas A., Mulukutla, Bhanu Chandra, Figueroa, Bruno
その他の著者: Massachusetts Institute of Technology. Department of Biological Engineering
フォーマット: 論文
言語:English
出版事項: Elsevier BV 2020
オンライン・アクセス:https://hdl.handle.net/1721.1/125974