Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profile during the course of cell culture processes accurately....

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Sumit, Madhuresh, Dolatshahi, Sepideh, Chu, An-Hsiang Adam, Cote, Kaffa, Scarcelli, John J., Marshall, Jeffrey K., Cornell, Richard J., Weiss, Ron, Lauffenburger, Douglas A., Mulukutla, Bhanu Chandra, Figueroa, Bruno
Weitere Verfasser: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier BV 2020
Online Zugang:https://hdl.handle.net/1721.1/125974

Online

https://hdl.handle.net/1721.1/125974

Ähnliche Einträge