Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures using Time Course Omics Analyses

N-linked glycosylation affects the potency, safety, immunogenicity, and pharmacokinetic clearance of several therapeutic proteins including monoclonal antibodies. A robust control strategy is needed to dial in appropriate glycosylation profile during the course of cell culture processes accurately....

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Bibliographic Details
Main Authors: Sumit, Madhuresh, Dolatshahi, Sepideh, Chu, An-Hsiang Adam, Cote, Kaffa, Scarcelli, John J., Marshall, Jeffrey K., Cornell, Richard J., Weiss, Ron, Lauffenburger, Douglas A., Mulukutla, Bhanu Chandra, Figueroa, Bruno
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125974

Internet

https://hdl.handle.net/1721.1/125974

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