Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

N-linked glycosylation in monoclonal antibodies (mAbs) is crucial for structural and functional properties of mAb therapeutics, including stability, pharmacokinetics, safety and clinical efficacy. The biopharmaceutical industry currently lacks tools to precisely control N-glycosylation levels during...

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Dades bibliogràfiques
Autors principals: Chang, Michelle, Gaidukov, Leonid, Jung, Giyoung, Tseng, Wen Allen, Scarcelli, John J., Cornell, Richard, Marshall, Jeffrey K., Lyles, Jonathan L, Sakorafas, Paul, Chu, An-Hsiang Adam, Cote, Kaffa, Tzvetkova, Boriana, Dolatshahi, Sepideh, Sumit, Madhuresh, Mulukutla, Bhanu Chandra, Lauffenburger, Douglas A, Figueroa, Bruno, Summers, Nevin M, Lu, Timothy K, Weiss, Ron
Altres autors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Idioma:English
Publicat: Springer Science and Business Media LLC 2020
Accés en línia:https://hdl.handle.net/1721.1/125977

Internet

https://hdl.handle.net/1721.1/125977

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