Small-molecule control of antibody N-glycosylation in engineered mammalian cells

Small-molecule control of antibody N-glycosylation in engineered mammalian cells

N-linked glycosylation in monoclonal antibodies (mAbs) is crucial for structural and functional properties of mAb therapeutics, including stability, pharmacokinetics, safety and clinical efficacy. The biopharmaceutical industry currently lacks tools to precisely control N-glycosylation levels during...

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Bibliographic Details
Main Authors: Chang, Michelle, Gaidukov, Leonid, Jung, Giyoung, Tseng, Wen Allen, Scarcelli, John J., Cornell, Richard, Marshall, Jeffrey K., Lyles, Jonathan L, Sakorafas, Paul, Chu, An-Hsiang Adam, Cote, Kaffa, Tzvetkova, Boriana, Dolatshahi, Sepideh, Sumit, Madhuresh, Mulukutla, Bhanu Chandra, Lauffenburger, Douglas A, Figueroa, Bruno, Summers, Nevin M, Lu, Timothy K, Weiss, Ron
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/125977

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