Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene expression remains unclear, largely because past studies using native and engineered sequences had insufficient scale. Here, we measure the expression output of >100 million synthetic yeast promoter sequences th...

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Bibliographic Details
Main Authors: de Boer, Carl G., Vaishnav, Eeshit Dhaval, Sadeh, Ronen, Abeyta, Esteban Luis, Friedman, Nir, Regev, Aviv
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/125982

Internet

https://hdl.handle.net/1721.1/125982

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