Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...

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Bibliographic Details
Main Authors: Brennan, Christopher M, Vaites, Laura Pontano, Wells, Jonathan N., Santaguida, Stefano, Paulo, Joao A., Storchova, Zuzana, Harper, J. Wade, Marsh, Joseph A., Amon, Angelika B
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory 2020
Online Access:https://hdl.handle.net/1721.1/125985

Internet

https://hdl.handle.net/1721.1/125985

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