Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory
2020
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| Online Access: | https://hdl.handle.net/1721.1/125985 |