Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehydrogenase (PHGDH). However, whether increased seri...

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Bibliographic Details
Main Authors: Sullivan, Mark Robert, Mattaini, Katherine Ruth, Dennstedt, Emily A, Nguyen, Anna, Sivanand, Sharanya, Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia, Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125987

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https://hdl.handle.net/1721.1/125987

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