The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation 1 . Mutations in DDX3 are linked to tumorigenesis 2-4 and intellectual disability 5, and the enzyme is targeted by a range of viruses 6 . How Ded1p and...

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Bibliographic Details
Main Authors: Guenther, Ulf-Peter, Weinberg, David E., Zubradt, Meghan M., Tedeschi, Frank A., Stawicki, Brittany N., Zagore, Leah L., Brar, Gloria A., Licatalosi, Donny D., Bartel, David, Weissman, Jonathan S., Jankowsky, Eckhard
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/125996

Internet

https://hdl.handle.net/1721.1/125996

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