Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

Fragile X syndrome (FXS), the most common genetic form of intellectual disability in males, is caused by silencing of the FMR1 gene associated with hypermethylation of the CGG expansion mutation in the 5′ UTR of FMR1 in FXS patients. Here, we applied recently developed DNA methylation editing tools...

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Bibliographic Details
Main Authors: Liu, X. Shawn, Wu, Hao, Krzisch, Marine, Wu, Xuebing, Graef, John, Muffat, Julien, Hnisz, Denes, Li, Charles Han, Yuan, Bingbing, Xu, Chuanyun, Li, Yun, Vershkov, Dan, Cacace, Angela, Young, Richard A., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126002

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https://hdl.handle.net/1721.1/126002

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