Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells
Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S-phase inhibitor Whi5 and defects in G1/S cyclin transcription cause cell cycle delays and genomic instability that r...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory
2020
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| Online Access: | https://hdl.handle.net/1721.1/126009 |