Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction

Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. Here, we used RNA-sequencing (RNA-Seq) to identify...

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Bibliographic Details
Main Authors: Nath, Samir R., Yu, Zhigang, Gipson, Theresa A., Marsh, Gregory B., Yoshidome, Eriko, Robins, Diane M., Todi, Sokol V., Housman, David E, Lieberman, Andrew P.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: American Society for Clinical Investigation 2020
Online Access:https://hdl.handle.net/1721.1/126010

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https://hdl.handle.net/1721.1/126010

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