Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction
Skeletal muscle has emerged as a critical, disease-relevant target tissue in spinal and bulbar muscular atrophy, a degenerative disorder of the neuromuscular system caused by a CAG/polyglutamine (polyQ) expansion in the androgen receptor (AR) gene. Here, we used RNA-sequencing (RNA-Seq) to identify...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2020
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| Online Access: | https://hdl.handle.net/1721.1/126010 |