Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix

Extracellular matrix (ECM) deposition is a hallmark of many diseases, including cancer and fibroses. To exploit the ECM as an imaging and therapeutic target, we developed alpaca-derived libraries of “nanobodies” against disease-associated ECM proteins. We describe here one such nanobody, NJB2, speci...

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Bibliographic Details
Main Authors: Jailkhani, Noor, Ingram, Jessica R., Rashidian, Mohammad, Rickelt, Steffen, Tian, Chenxi, Mak, Howard, Jiang, Zhigang, Ploegh, Hidde L., Hynes, Richard O
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/126031

Internet

https://hdl.handle.net/1721.1/126031

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