Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1–SIRT7) that mediate the benefits of exer...

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Bibliographic Details
Main Authors: Das, Abhirup, Huang, George X., Bonkowski, Michael S., Longchamp, Alban, Li, Catherine, Schultz, Michael B., Kim, Lynn-Jee, Osborne, Brenna, Joshi, Sanket, Lu, Yuancheng, Treviño-Villarreal, Jose Humberto, Kang, Myung-Jin, Hung, Tzong-tyng, Lee, Brendan, Williams, Eric O, Igarashi, Masaki, Mitchell, James R., Wu, Lindsay E., Turner, Nigel, Arany, Zolt, Guarente, Leonard Pershing, Sinclair, David A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126072

Internet

https://hdl.handle.net/1721.1/126072

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