Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer
Background: Pancreatic cancer is associated with development of cachexia, a wasting syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues or identified biomarkers predictive of future tissue wasting. Methods: Adipose and muscle tissue were measured by comp...
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| Format: | Article |
| Language: | English |
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American Association for Cancer Research (AACR)
2020
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| Online Access: | https://hdl.handle.net/1721.1/126075 |
| _version_ | 1826200584103919616 |
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| author | Babic, Ana Rosenthal, Michael H. Bamlet, William R. Takahashi, Naoki Sugimoto, Motokazu Danai, Laura V. Morales-Oyarvide, Vicente Khalaf, Natalia Dunne, Richard F. Brais, Lauren K. Welch, Marisa W. Zellers, Caitlin L. Dennis, Courtney Rifai, Nader Prado, Carla M. Caan, Bette Sundaresan, Tilak K. Meyerhardt, Jeffrey A. Kulke, Matthew H. Clish, Clary B. Ng, Kimmie Vander Heiden, Matthew G. Petersen, Gloria M. Wolpin, Brian M. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Babic, Ana Rosenthal, Michael H. Bamlet, William R. Takahashi, Naoki Sugimoto, Motokazu Danai, Laura V. Morales-Oyarvide, Vicente Khalaf, Natalia Dunne, Richard F. Brais, Lauren K. Welch, Marisa W. Zellers, Caitlin L. Dennis, Courtney Rifai, Nader Prado, Carla M. Caan, Bette Sundaresan, Tilak K. Meyerhardt, Jeffrey A. Kulke, Matthew H. Clish, Clary B. Ng, Kimmie Vander Heiden, Matthew G. Petersen, Gloria M. Wolpin, Brian M. |
| author_sort | Babic, Ana |
| collection | MIT |
| description | Background: Pancreatic cancer is associated with development of cachexia, a wasting syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues or identified biomarkers predictive of future tissue wasting. Methods: Adipose and muscle tissue were measured by computed tomography (CT) at diagnosis and 50 to 120 days later in 164 patients with advanced pancreatic cancer. Tissue changes and survival were evaluated by Cox proportional hazards regression. Baseline levels of circulating markers were examined in relation to future tissue wasting. Results: Compared with patients in the bottom quartile of muscle change per 30 days (average gain of 0.8 ± 2.0 cm2), those in the top quartile (average loss of 12.9 ± 4.9 cm2) had a hazard ratio (HR) for death of 2.01 [95% confidence interval (CI), 1.12-3.62]. Patients in the top quartile of muscle attenuation change (average decrease of 4.9 ± 2.4 Hounsfield units) had an HR of 2.19 (95% CI, 1.18-4.04) compared with those in the bottom quartile (average increase of 2.4 ± 1.6 Hounsfield units). Changes in adipose tissue were not associated with survival. Higher plasma branched chain amino acids (BCAA; P = 0.004) and lower monocyte chemoattractant protein-1 (MCP-1; P = 0.005) at diagnosis were associated with greater future muscle loss. Conclusions: In patients with advanced pancreatic cancer, muscle loss and decrease in muscle density in 2 to 4 months after diagnosis were associated with reduced survival. BCAAs and MCP-1 levels at diagnosis were associated with subsequent muscle loss. Impact: BCAAs and MCP-1 levels at diagnosis could identify a high-risk group for future tissue wasting. |
| first_indexed | 2024-09-23T11:38:38Z |
| format | Article |
| id | mit-1721.1/126075 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:38:38Z |
| publishDate | 2020 |
| publisher | American Association for Cancer Research (AACR) |
| record_format | dspace |
| spelling | mit-1721.1/1260752022-09-27T20:58:35Z Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer Babic, Ana Rosenthal, Michael H. Bamlet, William R. Takahashi, Naoki Sugimoto, Motokazu Danai, Laura V. Morales-Oyarvide, Vicente Khalaf, Natalia Dunne, Richard F. Brais, Lauren K. Welch, Marisa W. Zellers, Caitlin L. Dennis, Courtney Rifai, Nader Prado, Carla M. Caan, Bette Sundaresan, Tilak K. Meyerhardt, Jeffrey A. Kulke, Matthew H. Clish, Clary B. Ng, Kimmie Vander Heiden, Matthew G. Petersen, Gloria M. Wolpin, Brian M. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Background: Pancreatic cancer is associated with development of cachexia, a wasting syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues or identified biomarkers predictive of future tissue wasting. Methods: Adipose and muscle tissue were measured by computed tomography (CT) at diagnosis and 50 to 120 days later in 164 patients with advanced pancreatic cancer. Tissue changes and survival were evaluated by Cox proportional hazards regression. Baseline levels of circulating markers were examined in relation to future tissue wasting. Results: Compared with patients in the bottom quartile of muscle change per 30 days (average gain of 0.8 ± 2.0 cm2), those in the top quartile (average loss of 12.9 ± 4.9 cm2) had a hazard ratio (HR) for death of 2.01 [95% confidence interval (CI), 1.12-3.62]. Patients in the top quartile of muscle attenuation change (average decrease of 4.9 ± 2.4 Hounsfield units) had an HR of 2.19 (95% CI, 1.18-4.04) compared with those in the bottom quartile (average increase of 2.4 ± 1.6 Hounsfield units). Changes in adipose tissue were not associated with survival. Higher plasma branched chain amino acids (BCAA; P = 0.004) and lower monocyte chemoattractant protein-1 (MCP-1; P = 0.005) at diagnosis were associated with greater future muscle loss. Conclusions: In patients with advanced pancreatic cancer, muscle loss and decrease in muscle density in 2 to 4 months after diagnosis were associated with reduced survival. BCAAs and MCP-1 levels at diagnosis were associated with subsequent muscle loss. Impact: BCAAs and MCP-1 levels at diagnosis could identify a high-risk group for future tissue wasting. 2020-07-07T19:02:34Z 2020-07-07T19:02:34Z 2019-09 2019-05 2020-06-19T17:16:44Z Article http://purl.org/eprint/type/JournalArticle 1055-9965 1538-7755 https://hdl.handle.net/1721.1/126075 Babic, Ana et al. "Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer." Cancer Epidemiology Biomarkers and Prevention 28, 12 (December 2019): 2062–2069 © 2019 American Association for Cancer Research en http://dx.doi.org/10.1158/1055-9965.epi-19-0370 Cancer Epidemiology Biomarkers and Prevention Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for Cancer Research (AACR) PMC |
| spellingShingle | Babic, Ana Rosenthal, Michael H. Bamlet, William R. Takahashi, Naoki Sugimoto, Motokazu Danai, Laura V. Morales-Oyarvide, Vicente Khalaf, Natalia Dunne, Richard F. Brais, Lauren K. Welch, Marisa W. Zellers, Caitlin L. Dennis, Courtney Rifai, Nader Prado, Carla M. Caan, Bette Sundaresan, Tilak K. Meyerhardt, Jeffrey A. Kulke, Matthew H. Clish, Clary B. Ng, Kimmie Vander Heiden, Matthew G. Petersen, Gloria M. Wolpin, Brian M. Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title | Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title_full | Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title_fullStr | Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title_full_unstemmed | Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title_short | Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer |
| title_sort | postdiagnosis loss of skeletal muscle but not adipose tissue is associated with shorter survival of patients with advanced pancreatic cancer |
| url | https://hdl.handle.net/1721.1/126075 |
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