The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn

TorsinA is an ER-resident AAA + ATPase, whose deletion of glutamate E303 results in the genetic neuromuscular disease primary dystonia. TorsinA is an unusual AAA + ATPase that needs an external activator. Also, it likely does not thread a peptide substrate through a narrow central channel, in contra...

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Bibliographic Details
Main Authors: Demircioglu, Fatma Esra, Zheng, Weili, McQuown, Alexander J., Maier, Nolan K., Watson, Nicki, Denic, Vladimir, Egelman, Edward H., Schwartz, Thomas, Cheeseman, Iain M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/126079

Internet

https://hdl.handle.net/1721.1/126079

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