A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria

A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria

Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity—an approach that cannot be used to assess the bactericidal activity of antibiotics against bacteria in drug-tolerant states. To address this limitation, we developed a multiplexed assay that uses metabolism-s...

Full description

Bibliographic Details
Main Authors: Stokes, Jonathan, Gutierrez, Arnaud, Lopatkin, Allison J., Andrews, Ian W., French, Shawn, Matic, Ivan, Brown, Eric D., Collins, James J.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/126163

Internet

https://hdl.handle.net/1721.1/126163

Similar Items