A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria
Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity—an approach that cannot be used to assess the bactericidal activity of antibiotics against bacteria in drug-tolerant states. To address this limitation, we developed a multiplexed assay that uses metabolism-s...
Main Authors: | Stokes, Jonathan, Gutierrez, Arnaud, Lopatkin, Allison J., Andrews, Ian W., French, Shawn, Matic, Ivan, Brown, Eric D., Collins, James J. |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2020
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Online Access: | https://hdl.handle.net/1721.1/126163 |
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