Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems
Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such systems could open new avenues for prodrug valida...
Main Authors: | Nguyen, Hung VanThanh, Detappe, Alexandre, Harvey, Peter, Gallagher, Nolan, Mathieu, Clelia, Agius, Michael P., Zavidij, Oksana, Wang, Wencong, Jiang, Yivan, Rajca, Andrzej, Jasanoff, Alan Pradip, Ghobrial, Irene M., Ghoroghchian, Paiman Peter, Johnson, Jeremiah A. |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Published: |
Royal Society of Chemistry (RSC)
2020
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Online Access: | https://hdl.handle.net/1721.1/126188 |
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