Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting

BACKGROUND: Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC selectivity and PIC uptake is a major drawback limiting the efficacy of photoi...

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Bibliographic Details
Main Authors: Liang, Barry J, Pigula, Michael, Baglo, Yan, Najafali, Daniel, Hasan, Tayyaba, Huang, Huang-Chiao
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:English
Published: BioMed Central 2020
Online Access:https://hdl.handle.net/1721.1/126246

Internet

https://hdl.handle.net/1721.1/126246

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