Memory engrams: Recalling the past and imagining the future
In 1904, Richard Semon introduced the term “engram” to describe the neural substrate for storing memories. An experience, Semon proposed, activates a subset of cells that undergo off-line, persistent chemical and/or physical changes to become an engram. Subsequent reactivation of this engram induces...
| Hoofdauteurs: | , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
American Association for the Advancement of Science (AAAS)
2020
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| Online toegang: | https://hdl.handle.net/1721.1/126261 |
| _version_ | 1826194506161061888 |
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| author | Josselyn, Sheena A. Tonegawa, Susumu |
| author2 | RIKEN-MIT Center for Neural Circuit Genetics |
| author_facet | RIKEN-MIT Center for Neural Circuit Genetics Josselyn, Sheena A. Tonegawa, Susumu |
| author_sort | Josselyn, Sheena A. |
| collection | MIT |
| description | In 1904, Richard Semon introduced the term “engram” to describe the neural substrate for storing memories. An experience, Semon proposed, activates a subset of cells that undergo off-line, persistent chemical and/or physical changes to become an engram. Subsequent reactivation of this engram induces memory retrieval. Although Semon’s contributions were largely ignored in his lifetime, new technologies that allow researchers to image and manipulate the brain at the level of individual neurons has reinvigorated engram research. We review recent progress in studying engrams, including an evaluation of evidence for the existence of engrams, the importance of intrinsic excitability and synaptic plasticity in engrams, and the lifetime of an engram. Together, these findings are beginning to define an engram as the basic unit of memory. |
| first_indexed | 2024-09-23T09:57:10Z |
| format | Article |
| id | mit-1721.1/126261 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:57:10Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1262612022-09-30T17:55:24Z Memory engrams: Recalling the past and imagining the future Josselyn, Sheena A. Tonegawa, Susumu RIKEN-MIT Center for Neural Circuit Genetics Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences In 1904, Richard Semon introduced the term “engram” to describe the neural substrate for storing memories. An experience, Semon proposed, activates a subset of cells that undergo off-line, persistent chemical and/or physical changes to become an engram. Subsequent reactivation of this engram induces memory retrieval. Although Semon’s contributions were largely ignored in his lifetime, new technologies that allow researchers to image and manipulate the brain at the level of individual neurons has reinvigorated engram research. We review recent progress in studying engrams, including an evaluation of evidence for the existence of engrams, the importance of intrinsic excitability and synaptic plasticity in engrams, and the lifetime of an engram. Together, these findings are beginning to define an engram as the basic unit of memory. 2020-07-20T19:26:59Z 2020-07-20T19:26:59Z 2020-01 2020-07-16T17:03:32Z Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 https://hdl.handle.net/1721.1/126261 Josselyn, Sheena A. and Susumu Tonegawa. "Memory engrams: Recalling the past and imagining the future." Science 367, 6473 (January 2020): eaaw4325 © 2019 The Authors en http://dx.doi.org/10.1126/science.aaw4325 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Josselyn, Sheena A. Tonegawa, Susumu Memory engrams: Recalling the past and imagining the future |
| title | Memory engrams: Recalling the past and imagining the future |
| title_full | Memory engrams: Recalling the past and imagining the future |
| title_fullStr | Memory engrams: Recalling the past and imagining the future |
| title_full_unstemmed | Memory engrams: Recalling the past and imagining the future |
| title_short | Memory engrams: Recalling the past and imagining the future |
| title_sort | memory engrams recalling the past and imagining the future |
| url | https://hdl.handle.net/1721.1/126261 |
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