Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Regulation of cellular iron homeostasis is crucial as both iron excess and deficiency cause hematological and neurodegenerative diseases. Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellular iron homeostasis, develop diabetes. Irp2 post-transcriptionally regulates...

Full description

Bibliographic Details
Main Authors: Santos, Maria C. Ferreira dos, Anderson, Cole P., Neschen, Susanne, Zumbrennen-Bullough, Kimberly B., Romney, Steven J., Kahle-Stephan, Melanie, Rathkolb, Birgit, Gailus-Durner, Valerie, Fuchs, Helmut, Wolf, Eckhard, Rozman, Jan, de Angelis, Martin Hrabe, Cai, Weiling Maggie, Rajan, Malini, Hu, Jennifer, Dedon, Peter C, Leibold, Elizabeth A.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/126282

Internet

https://hdl.handle.net/1721.1/126282

Similar Items