DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

Synthetic phosphorothioate (PT) internucleotide linkages, in which a nonbridging oxygen is replaced by a sulphur atom, share similar physical and chemical properties with phosphodiesters but confer enhanced nuclease tolerance on DNA/RNA, making PTs a valuable biochemical and pharmacological tool. In...

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Bibliographic Details
Main Authors: Wang, Lianrong, Jiang, Susu, Deng, Zixin, Dedon, Peter C, Chen, Shi
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Oxford University Press (OUP) 2020
Online Access:https://hdl.handle.net/1721.1/126286

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https://hdl.handle.net/1721.1/126286

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