Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies

Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform nonlinear regulatory operations involved in cellular decision-making and signal processing. In this study, we apply this design principle to synthetic networks, te...

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Bibliographic Details
Main Authors: Bashor, Caleb J., Patel, Nikit, Choubey, Sandeep, Beyzavi, Ali, Kondev, Jané, Collins, James J., Khalil, Ahmad S.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2020
Online Access:https://hdl.handle.net/1721.1/126317