Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies
Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform nonlinear regulatory operations involved in cellular decision-making and signal processing. In this study, we apply this design principle to synthetic networks, te...
Main Authors: | Bashor, Caleb J., Patel, Nikit, Choubey, Sandeep, Beyzavi, Ali, Kondev, Jané, Collins, James J., Khalil, Ahmad S. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | English |
Published: |
American Association for the Advancement of Science (AAAS)
2020
|
Online Access: | https://hdl.handle.net/1721.1/126317 |
Similar Items
-
Understanding Biological Regulation Through Synthetic Biology
by: Bashor, Caleb, et al.
Published: (2018) -
Deciphering Transcriptional Dynamics In Vivo by Counting Nascent RNA Molecules.
by: Sandeep Choubey, et al.
Published: (2015-11-01) -
A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions
by: Khalil, Ahmad S., et al.
Published: (2014) -
Customizing cellular signal processing by synthetic multi-level regulatory circuits
by: Yuanli Gao, et al.
Published: (2023-12-01) -
Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity
by: Xu Zheng, et al.
Published: (2018-03-01)