Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

BACKGROUND: Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell RNA sequencing (scRNA-seq), it is in principle possible to do such an analysis for single cells. However, scRNA-seq data has chara...

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Bibliographic Details
Main Authors: Holland, Christian H, Tanevski, Jovan, Perales-Patón, Javier, Gleixner, Jan, Kumar, Manu Prajapati, Mereu, Elisabetta, Joughin, Brian Alan, Stegle, Oliver, Lauffenburger, Douglas A, Heyn, Holger, Szalai, Bence, Saez-Rodriguez, Julio
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: BioMed Central 2020
Online Access:https://hdl.handle.net/1721.1/126321

Internet

https://hdl.handle.net/1721.1/126321

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